The Cure Bowl will feature the South Florida Bulls hitting the field against the Old Dominion Monarchs on Wednesday, December 17, 2025.

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South Florida vs. Old Dominion Matchup Info

Game date: Wednesday, December 17, 2025
Game time: 5 p.m. ET
Location: Orlando, Florida
Venue: Camping World Stadium
TV channel: ESPN

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South Florida vs. Old Dominion Odds and Prediction

Spread favorite: Bulls (-6.5)
Moneyline: Bulls (-250), Monarchs (+202)
Total: 55.5 points
Pick ATS: South Florida (-6.5)
Pick OU: Over (55.5)
Prediction: South Florida 34, Old Dominion 24

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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South Florida vs. Old Dominion Betting Records and Insights

South Florida has compiled an 8-3-1 ATS record so far this year.
Old Dominion has covered seven times in 12 games with a spread this year.
The Bulls have an ATS record of 5-1-1 when playing as at least 6.5-point favorites this season.
The Monarchs have covered the spread when playing as at least 6.5-point underdogs in their only opportunity this season.
A total of seven out of 12 South Florida games this season have hit the over.
Old Dominion and its opponent have combined to hit the over five out of 12 times this year.